Affordable Hidden Gems For Office Spaces Exist In Aspen But You Need To Be In The Know To Find Them

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Affordable Hidden Gems for Office Spaces Exist in Aspen but You Need to be In The Know to Find Them

by

Ruth Kruger

Commercial space in Aspen is some of the most expensive in the United States, and for good reason, the amount of tourist traffic and the spending power they bring is second to none, but there are also many small businesses trying to operate in town that are not retail or restaurant based and need an office space to lease that is affordable, this can be challenging but not impossible.

There are many hidden gems to be found in Aspen that make an ideal office space to lease, but these are not easy to find and the affordable ones are snatched up fast. To get one of these beauties you need a commercial real estate broker who know the town and the landlords to be ahead of the rest of the businesses looking for a great office location. Many places do not go on the market, it is handled via word of mouth between landlords and agents in the know, it is a small town after all and one things Aspen does do is look after it s own. If you were to simply try to use the MLS for a real estate search of office space in Aspen it may appear there is not much available and what is could be out of your price range. But if you are working with a local agent with years of experience and ties to the local community there could be many options that you would never see otherwise.

[youtube]http://www.youtube.com/watch?v=hUUI31tj8Jg[/youtube]

There are also amazing locations with incredible views and lots of space that are off the beaten path, you need to an agent who knows town to show you these options. For example Ute Place tucked at the end of Ute Ave has a charming office suite with ski town architecture and a collection of successful small Aspen business operating in the spaces. You could walk around town for weeks looking for a space and never see this location. There are several of these jewels but you need to be in the know to get a lease at one.

Another popular option for office space in Aspen is the Old Victorians on Main Street that have been zoned for commercial use. These have the perks of a great location where you can walk to lunch and to the ski hill, and work in a spacious and charming renovated old Aspen home. This really captures the essence of living and working in a ski town.

The latest addition to the Aspen commercial community is the Obermeyer Place complex on the north side of town. Obermeyer Place was the vision of Aspen legend Klaus Obermeyer, the owner of the ski clothing empire. He worked with the community to create this location that is a great mix of residential and commercial space filled with office suites, a doctors office, fitness gyms and more, all less that two blocks from the downtown core.

Finding the right

office space

in Aspen is simply a matter of getting in with the right agent to help you find that dream location.

Kruger and Company, directed by Ruth Kruger has been in commercial real estate in Aspen, Colorado for almost twenty years. Their experience includes Aspen infill development analysis, asset management, evaluation, marketing, disposition and purchase, retail and office leasing, property management, redevelopment and historic renovation.

Article Source:

ArticleRich.com

The Changing Dynamics Of Rewards &Amp; Recognition

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“Can gratitude be part of a process beyond its moral trappings?”

Gratitude is not just a matter of good gesture but provides a far deeper impact on one’s life and attitude. It provides the charm for any help done to anyone. Gratitude makes one of the pinnacles of humanity, which is seen in action and stands better than mere words. As Henri Frederic Amiel says-

“Thankfulness is the beginning of gratitude. Gratitude is the completion of thankfulness. Thankfulness may consist merely of words. Gratitude is shown in acts.”

Have you ever wondered what is that one more important thing that keeps employees motivated to be the best self at work day in and day out? Appreciation. While words of appreciation and encouragement might be validating, they’re fleeting beyond a point.

Attracting talent is crucial, but what is more important is recognising talent in the workplace. Not just that: In the crossroads of people and change, carrot and stick, smarter rewards, and speedy perks, it is critical for HRs to create a reward strategy that articulates the expectation of both employer and employees.

Recognition in the Workplace:

Human interaction involves gratitude which helps to cherish the relationships among each other. It is more pronounced in any workplace which involves people willing to cooperate to combine skills and merit to produce necessary solutions. Skyhigh Marketing in their book” The Side effects of “Thank You” brings out the merits of Gratitude such as:

    • Ensure high productivity – Gratitude generates happiness which makes dopamine released to the brain, making it more productive
    • Reduced Stress Levels – Practicing Gratitude on a regular basis would help to reduce stress hormones. Being grateful ensures emotional and physical resilience
    • Foster Healthy Lifestyle: – Two major indicators of healthy living are the sleep patterns and immune system. Gratitude acts as a catalyst to attain happiness and joy
    • Social Recognition: Social sense of gratitude helps in building a healthy work culture between employers and employees
    • Increased focus at work: Recognition does not just foster health and happiness but it is a prime factor to increase focus at work.

Economical Aspects:

In the” The Side effects of the “Thank You” book, the authors describe the varying costs and effects of losing and rehiring an employee. This is prevalent in low paying jobs with high turnover rates as these jobs do bear pressure and thereby lose productivity and are the major cause of attrition. This goes higher in costs connected to high paying jobs also.

The best way forward is rather simple. Coming up with sturdy rewards and recognition strategy! At the end of the day, that’s the best way to let your employees know that they’re doing well.

Companies must invest more in building strong reward and recognition programs and must use modern technology such as a unified HRMS software in order to track the mood and morale of the employees and determine how to increase productivity by keeping employees motivated at work. An end to end HR Solution like Darwinbox, Cake HR, Bamboo HR, Namely etc can help in tracking productivity, giving and receiving effective feedback and appreciating and recognising employees by enabling peer-to-peer recognition. This will help in building a culture of recognition and gratitude at work.

Impact of Recognition In Times of COVID:

Many would like to show gratitude in the best of their times but rarely at the lowest point. And it becomes even more difficult to express gratitude when everyone across the world is under a crisis like COVID. A pandemic forces people not to interact, not to converse face to face, which would make people feel agitated when they are all alone at home with zero social life. The tendency will prevail as the work from home culture evolves to be permanent. Therefore, now when more than half of the corporate population across the world are working remotely it becomes even more important for HRs to focus on recognition to keep employees motivated which in turn will enhance productivity at work.

“As we express our gratitude, we must never forget that the highest appreciation is not to utter words, but to live by them.” – John F. Kennedy

While formal recognition programs like annual employee awards are valuable, recognition shouldn’t be restricted to once in a year affair. It should be continuous and holistic. HR should encourage managers to recognize their reportees and peers in impromptu ways. With employees working from home, managers could start their virtual meetings by calling out good work done by the employees from the past week. In addition to regular meetings, managers should also encourage their team to set up virtual celebrations where anyone can voice their appreciation for each other. These virtual get-togethers can help foster connectivity at a time when people need it most.

Ways of Gratitude:

Gratitude is not a measurable quantity that can be judged but seen as a matter of human quality which is inseparable from motivation and productivity. This is the key to a healthy and productive workspace, enabling gratitude to be a primordial virtue.

A way of recognition is by peer to peer appreciation where colleagues could show the impact of gratitude more profoundly, enabling the workplace to be holistic and stress-free. This would be more crucial when the workplace is online oriented, where the colleagues are unable to meet face to face in this crisis.

Another is to create a ratio where both praise and criticism is used to judge a service or event on an employee. This may at least force the employee to work more to better interact with their peers and clients. The measure of gratitude should not restrict to only this ratio, but also involve the following methods(Summer Allen, “ The Science of Gratitude”)

  • The Gratitude Adjective Checklist(GAC)- This involves the employees to report a 1- 5 scale on the basis of these adjectives of gratitude, thankful and appreciative for any time period.
  • The Gratitude Questionnaire(GQ-6) – It is designed to measure the level of gratitude of a person as a “ trait gratitude” using a 6 value set.
  • The Gratitude Resentment and Appreciation Test(GRAT)- Another way to measure trait gratitude, with a rating system on a series of statements

These ways are only possible if the workspace encourages trust-building, promotes transparency, be open and tolerant of others’ views and opinions. It’s only possible if the workforce engages itself towards the feeling of esprit de corps. To express such an approach of gratitude, it is recommended to adopt these three simple practices at work.

  • Formulate a reward strategy
  • Maintain a recognition journal
  • Come up with innovative ways of recognition like-
  1. time-off to be used at a future date,
  2. free breakfast or lunch for those still coming into work,
  3. gift cards to local restaurants

How To Beat A Speeding Ticket Learn The Secrets To Winning In Court

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By John Oleander

Ways on how to beat speeding ticket is not manifested the moment you acquire a violation and the time your ticket has been given to you. Fighting off a traffic ticket can be averted when you know what not to do and what you must do so as not to incur the disturbing sight of an officer as well as the alarming vision of a speeding ticket.

How to beat speeding ticket can be prevented only if you know how to properly adhere with the road’s policies. A lot of drivers would agree to the statement that in order to win in court, offenses and violations should not be admitted on the spot. If an officer waves at your car while on the road and lay down the law with your over speeding offenses, acknowledgment of one’s act is not a competent thing to do. If the officer doesn’t seem to give an ear with all your elucidation and details of your story; bringing all the matters to court with a skilled lawyer is considered an optimum solution to take.

Nevertheless, you can never break away from an over speeding violation if you don’t know how to beat speeding ticket. Although, this idea might sound odd on most drivers; acting as if you are not aware of such violation can also help you eliminate the sight of a ticket. This works to some yet, not frequently. Thus, acting as if you don’t have any idea of such offenses might only lead to more harm than good. As the law implies, “Ignorance of the law excuses no one”, which simply explicates that those violators not knowledgeable and well informed about the rules of the road has no place in steering those wheels. Until you are proven guilty in court, you are still considered innocent.

[youtube]http://www.youtube.com/watch?v=uIgcKC-b_FA[/youtube]

You can also overcome and know how to beat speeding ticket if unforeseen circumstances like an officer not showing up takes place. Keep in mind that the moment the officer in charge in your case is not able to put in an appearance then there are greater tendencies that you can win your case. In most case proceedings, a customary set up begins with a judge calling your case. Once called, the officer will provide his state under oath. You can question the officer and lay your witnesses in front of court and both you and the officer can make your own concluding accounts.

How to beat speeding ticket also requires a knowledgeable background when it comes to the course of your violation. This is a salient aspect for a missed code during an officer’s statement can help you win the case. Irrelevant evidences can also be objected if you presume that such proofs can lead to your doom.

You can also triumph over a speeding ticket if you can formulate and object questions that might send some confusion to the officer not unless he is well versed with all the happenings the day he pulled your car over and issued a ticket. Thus, if you don’t want to increase your insurance rates and win in court; you better be beating that speeding ticket now!

About the Author: Ready to learn

how to beat a speeding ticket

? Learn how to get out of it 100% with NO FINE and NO POINTS on your record. The method works and is LEGAL!! Go to

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Get Lowest Budget Vacation Packages At Hungry Bags

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Submitted by: Aanchal Gupta

If you wish to have a stress free holiday with your family, friends or simply all along, the idea of cheap vacation packages seems to be quite tempting one. No need to worry about anything as the travel company will plan everything for you right from booking the flight tickets to planning out a detailed itinerary. Plus, the best part about vacation packages is that you get to know with a reasonable degree of certainty about the total amount of money you will have to spend for the holiday.

Budget is always one of the first points when one decides to go on a holiday or a vacation. Price factor plays a major role when one look up for transportation and transfers, food and beverage choices, room extras and resort facilities. This is when cheap vacation packages seem to be of huge benefit. Just look around the World Wide Web and you will come across a wide number of travel and tour operators offering all inclusive cheap vacation packages to a number of destinations including India, Europe, Maldives, Mauritius, Spain, Mexico and Hong Kong to name a few.

[youtube]http://www.youtube.com/watch?v=DMPyD1mcNW0[/youtube]

There are vacation packages that offer a diverse range of accommodation types along with various other car rental services and itinerary details. In fact, there are packages also where one can even investigate holiday accommodations online and decide the accommodation that is the right one for them. As online travel companies do all the researching work for one to find the best travel deals, all the miniscule bits have been arranged and all the traveler must do is arrive and enjoy their time away.

In general, in vacation packages your flights, accommodation, meals, local drinks and entertainments as described in the brochure are included. And for everything you just need to make the payment once. After that you simply don t have to worry about anything but be ready to enjoy a dream holiday at the destination of your choice.

The itinerary planned out by the travel companies in the vacation packages offered by them are the best one. Particularly, travel companies have ample knowledge about a destination and are aware of the top attractions there. Hence, they prepare an itinerary keeping in mind the interests and preferences of varied customers. There are some holiday packages where one can include a thing or two of their interest after discussing the same with the travel companies.

Also getting a travel agent to help with your holiday arrangement gives the additional help of local knowledge. The safest periods to travel while understanding the weather and climate of the destination, helping you avoid the most crowded times of the year and accommodation that is most appropriate for a traveler.

To conclude, holiday packages are the best way to plan and enjoy a holiday anytime and anywhere. However, before you book any cheap vacation packages, make sure that you know exactly what is and isn’t included. Moreover, no one wants to have a bad holiday and proper research will ensure that you have the best holiday every time.

About the Author: Hungry Bags is a travel company that offers complete information on tour and travel industry and also provides the best holiday packages, vacation packages and cheap vacation Packages in the market.

hungrybags.com/vacation-packages/

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isnare.com

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How To Find The Best Hot Tubs In Pearland

  By

byadmin

Finding ways to increase the appeal and functionality of a home is a lot harder than most people realize. A homeowner will need to do a great deal of research before choosing additions for their residence. If a person is looking for a way to add a higher degree of relaxation to their residence, investing in Hot Tubs in Pearland is a great idea.

There are a number of hot tubs on the market. That is why a homeowner will have to do their homework before choosing one. Here are just some of the things a homeowner needs to focus on when trying to get the best hot tub.

Where Will the New Hot Tub Be Installed?

Before heading out to look at hot tubs, a homeowner needs to get an idea of where they want to put it. If the home has a deck, a person may want to think about putting their hot tub on it. Once a homeowner has made a decision on where to put the hot tub, they will need to take some measurements.

With these measurements, a homeowner will have no problem narrowing down the selection of hot tubs on the market. Going into this buying process without this type of information will generally lead to mistakes being made.

Choosing the Right Supplier

The key to getting the right hot tub is finding a reputable and experienced supplier. Before a person uses a particular hot tub supplier, they will need to do some research. Finding out how long a supplier has been in business and what type of track record they have is essential.

Once a homeowner has the important information, they should have no problem making this important decision. Getting some guidance from professionals can help a homeowner avoid making costly mistakes.

The money paid for quality hot tubs in Pearland will be worth it considering how much enjoyment a hot tub can provide. The team at Cryer Pools have quality hot tubs at very affordable prices. Call them or click here to get a look at the hot tubs they have in stock and to see how much they charge.

Get The Look: Hairstyle Tips}

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GET THE LOOK: HAIRSTYLE TIPS

by

Gurjinder is a online marketer. A writer by day and reader by night. He has been in internet marketi

In this article for today you can see the easiest ways for making great hairstyle and trust me it can be done for less than a minute. Maybe you will not believe when you read this but yes dear girls when you will see the tutorial you will be sure in that. Making of these stunning ideas will change your look and whatever they are easy but they look chick and trendy

Your hairstyle is a reflection of your personality. So have fun with it or keep it clean cut, whether you have long or short, straight or curly hair. these tips can get you the hot look you’re looking for. Be sure to match the hairstyle that best suits your face shape.

[youtube]http://www.youtube.com/watch?v=yTi6nDqM62I[/youtube]

Oval/Round Shaped- For a round shaped face you want to have a little more length all over. Also, a goatee is a great accent for this face type. You want to draw more attention to your locks by keeping more length. A pomade styled spike looks great too.

Square Shaped- Men with a square shaped jaw line want to make their face look slightly leaner and less box-like. We recommend a short cut or shave with a light close to skin all over beard. Simply grow your facial hair out for several weeks and then use clippers to keep the length short. Try AXE Messy Look Paste and comb through your hair with your fingers for a relaxed but stylish look.

Triangular-With this jaw line you have a more prominent chin. You want to balance it with longer length at the crown, shorter side burns. A full beard will also help soften your features. A slicked back look is always sheik or a lightly gelled casual style is great for any occasion. For optimal beard shaving and grooming.

Rectangular/Oblong Shaped- If you have this face shape, a beard is a great way to balance your features out by visually shortening the length of your face while creating the illusion that your face is more oval. Keep hair length at 2 inches max at crown and keep sides slightly shorter. Keep hair in place with a firm gel.

If you have an oblong face shape, you’ll know that it can present some challenges when it comes to finding the right hairstyle. Oblong faces are more long than they are wide, and typically have a narrow appearance to them. As an oblong, you’ll want to reduce any excess length in your face and add some bulk and body to add width. You may also have to contend with a high forehead and prominent chin, which are common features with this face shape.

In general, you will want to avoid severe centre parts, stick straight long hairstyles that can create further length, and styles that bring attention to your forehead. A fringe is an oblong’s best friend! To get an idea of what suits your face best, check out these latest hairstyles that are best suited for oblongs.

Pear/Diamond Shaped- With this face shape, incorporating side burns into your hairstyle will give your face a strong masculine look with balance. A short style shaved or cut at 1.5inches compliments this face shape best. A light stroke across the hair tips of Precision Putty by Gillette with give this look a stylish shine and light hold.

Gurjinder is a online marketer. A writer by day and reader by night. He has been in internet marketing industry since 1 years and specializes in Digital Marketing.

Article Source:

eArticlesOnline.com
}

Intimate Apparel Supports Many Fashion Styles

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By James Brown

Intimate apparel is worn against the body under many types of clothing. Some women require intimate apparel for wear during a certain time of the day, and they will find intimate apparel that clings and does not allow the body to breathe to be very uncomfortable in a short time. Intimate apparel such as slips, brassieres and girdles must be comfortable enough to wear on any occasion and finding a good fit in those items may take a considerable amount of time that most women do not have.

Some fashion styles that incorporate skirts into the mix, will give women intimate apparel choices that are very limited. There are slips that would fit the style needs of a fashionably dressed woman. Some intimate apparel choices that would work best with the knit tops worn with skirts would be chemises or camisoles that are styled to be very brief. A woman needs to wear intimate apparel that moves with the body and will often avoid pretty lingerie because it is binding.

Some surgical procedures might require women to change their styles in clothing. A woman that has had a mastectomy might find revealing fashions to be very unappealing. With the correct brassieres that are fashioned to transform a woman’s appearance after she had had such surgery, it is possible to find many fashions desirable and comfortable to wear for many occasions. There are breast forms that can be placed inside brassieres to make women seem bustier.

[youtube]http://www.youtube.com/watch?v=M6ZjMWLqJvM[/youtube]

A bride will be the bell of the ball when she is wearing intimate apparel that gives her shape and support under the various layers of her wedding gown. Brides are thrilled to wear specially made corsets under their wedding gowns. A bride will quickly realize how these intimate apparel items can accessorize the dress form during the day and prove to be very alluring when worn on the wedding night.

A bride will feel very special and unique while wearing intimate apparel that is frilly and decorative and noticeably the color of pure white. She has the choice of wearing nothing underneath the gown but still have intimate apparel that will prove to be some fun at the reception. The bride can wear garters made of lace that they husband can remove, while still wearing intimate apparel that makes her feel extremely sexual and dainty at the same time.

A woman can boost her sensuality by wearing intimate apparel that is silky against the skin. She can maintain a wardrobe of lingerie that range from panties that rise high on the leg to underwear that is barely there and can be tied together with one or two knots. The brassieres can be very intimate to because some of the styles fasten in the front and some from the side. A woman can express her fashion tastes just by the type of undergarments she chooses to wear. Some of these items might be intimate apparel that is never seen in public but the wearer is very conscious that it is there.

About the Author: James Brown writes about Lew Magram discounts, Shopbop.com coupons and Monterey Bay Clothing Company coupon code

Source: isnare.com

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Why Do You Need To Change Your Career?

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By James Copper

Is the thought ‘change your career’ coming to your mind frequently nowadays? Is it because you are unhappy with what you are currently doing? Is it that you want to do something completely different?

If the answer to these questions is ‘yes’, then maybe you need to change your career.

Why Do Such Situations Arise?

There are many reasons why people after working for a few years decide that they want to do something else. Why would you want a change? Possibly because of one of the following reasons:

– You are bored with what you are doing.

– There are limited opportunities for career enhancement in your field. You are likely to retire doing what you were doing when you joined the company.

[youtube]http://www.youtube.com/watch?v=M4IwXYLm4Ws[/youtube]

– The job you do is so specialized and has such limited application that the chances of you getting a similar job in some other organization are limited.

– You feel like you are wasting the best years of your life in a mundane job doing mundane work every day of the week. You want to do something different and more meaningful.

– New careers and job opportunities which did not exist when you started working have opened up. You feel that one such career might be the one or you.

– Your personal situation has changed since the time you started working. As a twenty-three year old marketing executive you were ready to pick up a bag and travel at a day’s notice. Twelve years hence, with three children, traveling is a difficult option for you. Hence you want to change your career.

– A similar situation might arise because of health problems. If your job entailed long hours spent standing but a recent injury means that you need to sit down as much as possible, your situation might require you to consider alternate career options.

What Should You Do?

Though you might believe that the only thing which will make you happy is a change in your career, in reality that may not be true. You must therefore dispassionately analyze your situation. Keep the following in mind while doing so:

– Are you bored with the job or with your organization? Do you think you will be happy doing the same or similar job in a different company? If yes, then what you need to do is change your job, and not change your career.

– Have you done adequate research and put in enough thought on the amount of retraining a new career will entail? It will also mean that you lose out on the benefits of your many years of experience in your current job.

– Choose a career where some of your existing skills will be of use. For instance, if you have a couple of years of experience in client interface this might be of use in a new career as well. If you change your career in such a manner that you can leverage your existing skills, you will be better off.

When you decide to change your career, it can be a momentous moment in your life; therefore do your homework well before taking the plunge.

About the Author: James Copper writes on all types of internet marketing related topics including courses from the marketing college

Source: isnare.com

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Dyslexia Treatment Options

  By

In addition, dyslexics may have trouble writing because of poor hand-eye coordination and will also have problems with math, visual cues, remembering instructions or concepts, and dealing with emotional problems. When a parent or individual thinks that their child or themselves may have symptoms of dyslexi, it’s important to complete a dyslexia assessment so a medical professional can determine whether or not signs of dyslexia are present. Once dyslexia is diagnosed the individual can begin dyslexia treatment, which will help them learn better and perform simple tasks easier, like communication with peers, completing homework on time, and continuing to develop visual and motor skills.The reason why people are dyslexic may vary, but many experts agree that dyslexia is brain damage that greatly affects and individuals cognitive, ‘thinking’ functions. There are many different types of dyslexia treatment available for children and adults alike. Doing verbal exercises may be the best way to help treat dyslexia. Some of these approaches may include rhyming exercises, defining the differences between spoken sounds, slowly blending sounds into words, word matching, picking out the verbal sounds in certain words, and removing verbal sounds from words. A speech pathologists is usually the best person to speak with when doing verbal dyslexia treatment. Speech pathologists can usually be found at schools, non-profit organizations, and in private practices. Usually the child’s school can provide resources.In addition, other methods that can be used for dyslexia treatment include steady repetition of saying the word, writing the word, then repeating the word. After a few words have been mastered using this system, then a new batch of words is introduced. Once these have been mastered, the original batch of words is introduced and attempted to be written and/or spoken from memory. While this approach may be time-consuming and a little frustrating for both educators and their students, experts have found that repetition, along with utilizing several different ‘types’ of communication (speaking, writing, and reading) is an effective method for teaching those suffering from dyslexia how to speak, write, and learn effectively.Besides utilizing professional resources to get help with dyslexia, there are at-home treatments and exercises that can be done to speed up the treatment and helping process. For instance, the American College of Homeopathy has a few suggestions, including reading with the child regularly, playing spelling games, praising the child when they make improvement, and tracing letters and words with the child while helping them sound them out. It’s also important to ask the child’s assigned counselor or speech pathologist for suggestions of any other exercises that may benefit the child and help them with their learning process. Dyslexia has no cure, but it can be managed with regular treatment.

[youtube]http://www.youtube.com/watch?v=P_OGCPfpXLo[/youtube]

Combination Therapy Cancer Treatment In India At Mumbai And Bangalore At Low Cost.

  By

Submitted by: P Nagpal Nagpal

Combination Therapy

Combination therapy may benefit patients with specific genetic subtype of non-small cell lung cancer, study finds

Even when their tumors are shrinking in response to therapy, some non-small cell lung cancer (NSCLC) patients have a scattering of cancer cells that are undeterred by the drug, causing the tumor to resume its growth, Dana-Farber Cancer Institute and Massachusetts General Hospital (MGH) Cancer Center scientists report in the January issue of Cancer Cell. The findings suggest that identifying such patients and treating them with a combination of drugs from the very start of therapy can produce longer remissions.

One of the triggers for resistance, the researchers found, is HGF, a ligand or “hook” that activates the MET protein.

When activated, HGF works through two entirely different channels to produce drug resistance, the authors report. First, it can generate cell-growth signals through a protein called GAB1. Second, it expands the number of MET-amplified cancer cells, ensuring they will become the dominant type in the lung tumors.

[youtube]http://www.youtube.com/watch?v=jP20Z9NL7Y0[/youtube]

“Not only can HGF spur cell growth on its own, it can speed up the process by which MET-amplified cells emerge and take over the composition of the tumor.

Combination therapy may benefit patients with specific genetic subtype of non-small cell lung cancer, study finds

Even when their tumors are shrinking in response to therapy, some non-small cell lung cancer (NSCLC) patients have a scattering of cancer cells that are undeterred by the drug, causing the tumor to resume its growth, Dana-Farber Cancer Institute and Massachusetts General Hospital (MGH) Cancer Center scientists report in the January issue of Cancer Cell.

The findings suggest that identifying such patients and treating them with a combination of drugs from the very start of therapy can produce longer remissions.

One of the triggers for resistance, the researchers found, is HGF, a ligand or “hook” that activates the MET protein.

In about 20 percent of NSCLC patients who are resistant to Tarceva the mechanism is amplification of MET, and in another 20 percent it may involve HGF.

The findings suggest that patients whose NSCLC tumors harbor even a few MET-amplified cells prior to treatment would benefit from drugs that specifically target those cells, in combination with a tyrosine kinase inhibitor. J nne notes that such drugs are already being studied in clinical trials.

A thorough analysis of a patient’s cancer prior to treatment can establish how it would ultimately develop resistance to therapy, allowing us to tailor treatment with greater precision to prevent resistance.

“For example, cancers found to harbor a small population of cells with pre-existing MET amplification will likely benefit from adding MET inhibitors to initial treatment. Those without such cells may not benefit, and these patients can avoid the added toxicity of MET inhibitors and instead focus on other strategies to prevent their cancers from becoming resistant.”

Please log on to :http://www.cancertreatment-wecareindia.com/treatment/chemo_therapy.html

Please log on to :http://www.cancertreatment-wecareindia.com/treatment/combination_therapy.html

Contact Email : info@cancertreatment-wecareindia.com

About the Author: Pankaj Nagpal – About the Author:Welcome to World Class Treatment and Surgery by We Care Health Services, India. Contact Us : www.indiahospital

tour.com

|| E-mail us on : info@indiahospitaltour.com || Contact Center Tel. :(+91) 9029304141. The surgery and medical treatments offered by We Care Health Services at JCI Accredited / ISO Certified Hospitals are vast and varied; ranging from Heart Surgery in India, Cardiology to Cardio Thoracic surgery, Total Knee / Hip / Ankle / Shoulder Joint Replacement Surgery in India including ACL reconstruction Surgery to Birmingham Hip Resurfacing Surgery in India , Spine Surgery in India like Discectomy / Laminectomy Surgery, Cervical Decompression to Anterior / Posterior Spinal Fusion Surgery in India, Chemotherapy, Radiotherapy, Cancer surgery, Sterotactic Radiotherapy, Autologous / Allogenic Bone Marrow Transplant Surgery to Breast Cancer treatments, Near relative Kidney Transplant Surgery to Dialysis and Kidney Biopsy, Low Cost Liver Transplants Surgery, Hysterectomy (Vaginal / Abdominal) to Ovarian Cystectomy, Hernia repair Surgery to Cholecystectomy, Advanced Neurosurgery in India, Bariatric surgery, Gastric Bypass Surgery in India, Eye Surgery in India, Cornea Transplant, Cataract Surgery to LASIK Eye care Surgery, IVF, ICSI, Egg Donor to Surrogacy, Minimally Invasive surgery or Laparoscopic Surgery to Cochlear Implants, Breast Lift / Tummy Tuck, Face Lift to Low Cost Rhinoplasty Cosmetic Surgery, multi specialty Hospitals in India offering first world treatments with board certified highly qualified medical consultants in attendance at third world prices..

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